Apoptosis

Description: Mouse monoclonal CDCP1 antibody

Description: Mouse monoclonal CDCP1 antibody

Description: Mouse monoclonal CDCP1 antibody

Description: Mouse monoclonal CDCP1 antibody

Description: Mouse monoclonal CDCP1 antibody

Description: Rabbit polyclonal CDCP1 antibody

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:5000, WB:1:1000-1:5000, IHC:1:50-1:200

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Description: A polyclonal antibody against CDCP1. Recognizes CDCP1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

Description: Additional name(s) for this target protein: CUB domain containing protein 1

Description: CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

Description: For Quantitative Detection of human CDCP1 in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Description: Description of target: CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <2pg/ml

Description: Description of target: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.6 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer."_x005F_x005F_x000D_Scherl-Mostageer M., Sommergruber W., Abseher R., Hauptmann R., Ambros P., Schweifer N._x005F_x005F_x000D_Oncogene 20:4402-4408(2001) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT GLY-709.Ref.3"Adhesion signaling by a novel mitotic substrate of src kinases."_x005F_x005F_x000D_Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M._x005F_x005F_x000D_Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 30-34 AND 369-375, IDENTIFICATION BY MASS SPECTROMETRY, PHOSPHORYLATION, GLYCOSYLATION, TISSUE SPECIFICITY, INTERACTION WITH CDH2; CDH3; SDC1; SDC4 AND ST14, FUNCTION.Ref.9"Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein."_x005F_x005F_x000D_Xia Y., Gil S.G., Carter W.G._x005F_x005F_x000D_J. Cell Biol. 132:727-740(1996) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, PHOSPHORYLATION.Ref.10"CDCP1 is a novel marker for hematopoietic stem cells."_x005F_x005F_x000D_Conze T., Lammers R., Kuci S., Scherl-Mostageer M., Schweifer N., Kanz L., Buehring H.-J._x005F_x005F_x000D_Ann. N. Y. Acad. Sci. 996:222-226(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin."_x005F_x005F_x000D_Buehring H.-J., Kuci S., Conze T., Rathke G., Bartolovic K., Gruenebach F., Scherl-Mostageer M., Bruemmendorf T.H., Schweifer N., Lammers R._x005F_x005F_x000D_Stem Cells 22:334-343(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY.Ref.13"Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS."_x005F_x005F_x000D_Andre M., Le Caer J.-P., Greco C., Planchon S., El Nemer W., Boucheix C., Rubinstein E., Chamot-Rooke J., Le Naour F._x005F_x005F_x000D_Proteomics 6:1437-1449(2006) [PubMed] [Europe PMC] [Abstract]Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.124 ng/mL