apoptosises

Evolution of altruistic cooperation among nascent multicellular organisms.

Cooperation is a classic solution to hostile environments that limit individual survival. In extreme cases this may lead to the evolution of new types of biological individuals (e.g., eusocial super-organisms).

We examined the potential for interindividual cooperation to evolve via experimental evolution, challenging nascent multicellular “snowflake yeast” with an environment in which solitary multicellular clusters experienced low survival. In response, snowflake yeast evolved to form cooperative groups composed of thousands of multicellular clusters that typically survive selection.

Group formation occurred through the creation of protein aggregates, only arising in strains with high (>2%) rates of cell death. Nonetheless, it was adaptive and repeatable, although ultimately evolutionarily unstable.

 

Extracellular protein aggregates act as a common good, as they can be exploited by cheats that do not contribute to aggregate production. These results highlight the importance of group formation as a mechanism for surviving environmental stress, and underscore the remarkable ease with which even simple multicellular entities may evolve-and lose-novel social traits.

Selection for synchronized cell division in simple multicellular organisms.

The evolution of multicellularity was a major transition in the history of life on earth. Conditions under which multicellularity is favored have been studied theoretically and experimentally.

 

But since the construction of a multicellular organism requires multiple rounds of cell division, a natural question is whether these cell divisions should be synchronous or not. We study a population model in which there compete simple multicellular organisms that grow by either synchronous or asynchronous cell divisions.

We demonstrate that natural selection can act differently on synchronous and asynchronous cell division, and we offer intuition for why these phenotypes are generally not neutral variants of each other.

 

apoptosises
apoptosises

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415215-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-200ul 200 ul
EUR 460.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-01mg 0.1 mg
EUR 644.4

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-01mg 0.1 mg
EUR 661.2

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx412054-01mg 0.1 mg
EUR 844.8

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody (FITC)

abx415209-01mg 0.1 mg
EUR 610.8

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

32146-05111 150 ug
EUR 313.2

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE)

abx415207-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC)

abx415212-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE)

abx415214-100tests 100 tests
EUR 710.4

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

20-abx174727
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-400ul 400 ul
EUR 627.6

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-80l 80 µl
EUR 343.2

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

20-abx318087
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

20-abx178542
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

4-RPH854Hu01
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) expressed in: E.coli

TIM3 (T-Cell Immunoglobulin)/HAVCR2

MO47039 100 ul
EUR 418.8

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (Biotin Conjugate)

32146-05121 150 ug
EUR 442.8

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

20-abx655199
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP)

20-abx316455
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC)

20-abx316456
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin)

20-abx316457
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 132
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Rac2 Activation Assay Kit, Trial Size

STA-401-2-T 5 assays
EUR 483.6
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Rap2 Activation Assay Kit, Trial Size

STA-406-2-T 5 assays
EUR 483.6
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric, Trial Size

CBA-135-T 24 assays
EUR 518.4
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

CytoSelect 96-Well Cell Transformation Assay (Cell Recovery Compatible, Fluorometric), Trial Size

CBA-140-T 24 assays
EUR 547.2
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

CSB-EL023546HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

1-CSB-EL023546HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (FITC Conjugate)

32146-05141 150 ug
EUR 513.6

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (RPE Conjugate)

32146-05151 150 ug
EUR 513.6

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (APC Conjugate)

32146-05161 150 ug
EUR 513.6

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (PerCP Conjugate)

32146-05171 150 ug
EUR 565.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

20-abx153299
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ELISA Kit

abx352339-96tests 96 tests
EUR 943.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) CLIA Kit

20-abx495562
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RD-TIMD4-Hu-48Tests 48 Tests
EUR 625.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RD-TIMD4-Hu-96Tests 96 Tests
EUR 867.6

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RDR-TIMD4-Hu-48Tests 48 Tests
EUR 652.8

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RDR-TIMD4-Hu-96Tests 96 Tests
EUR 907.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

4-SEH854Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit (TIMD4)

RK02389 96 Tests
EUR 625.2

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

ELISA kit for Human TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4)

E-EL-H5515 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human TIMD4 (T-Cell Immunoglobulin And Mucin Domain Containing Protein 4)

ELK4680 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

KTE62326-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

KTE62326-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

KTE62326-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Anti-Mucin 2 antibody

STJ16100978 1 mL
EUR 716.4

CytoSelect 24-Well Cell Migration Assay (8 µm, Colorimetric Format), Trial Size

CBA-100-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect 24-Well Cell Migration Assay (8 µm, Fluorometric Format), Trial Size

CBA-101-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect 24-Well Cell Migration Assay (5 µm, Fluorometric Format), Trial Size

CBA-102-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

CytoSelect 24-Well Cell Migration Assay (3 µm, Fluorometric Format), Trial Size

CBA-103-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes.

CytoSelect 24-Well Cell Invasion Assay (Basement Membrane, Colorimetric Format), Trial Size

CBA-110-T 4 assays
EUR 386.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells.

CytoSelect 24-Well Cell Invasion Assay (Basement Membrane, Fluorometric Format), Trial Size

CBA-111-T 4 assays
EUR 386.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells.

CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation), Trial Size

CBA-130-T 24 assays
EUR 463.2
Description: Our CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation) is suitable for measuring cell transformation where no downstream analysis is required. Cells are incubated in a semisolid agar medium for 7-8 days. The cells are then solubilized, lysed and detected using the included fluorescent dye in a fluorometric plate reader.

SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion

E80026
  • EUR 588.50
  • EUR 823.90
  • 20 ul
  • 50 ul

Jurkat T / GFP Stable Cell (Flt1 Promoter)

SC049-2 2 x 106 cell/ml x 1ml
EUR 1800
Description: GFP expression stable cell line in human Jurkat T Cells with Puromycin resistance. GFP is expressed under the promoter of human Flt1 gene.

T-Pro Stacking Buffer

JB03-C002 500ml/BT
EUR 182.4

T-Pro MycoClean spray

JT90-R002 500ml/BT
EUR 172.8

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Anti-Adiponectin Receptor 2 (mouse) Antibody

A02218-2 200ug
EUR 597.6
Description: Goat Polyclonal Adiponectin Receptor 2 (mouse) Antibody. Validated in IF, IHC and tested in Mouse.

Caenorhabditis Sieve: A Low-tech Instrument and Methodology for Sorting Small Multicellular Organisms.

Caenorhabditis elegans (C. elegans) is a well-established model organism used across a range of basic and biomedical research. Within the nematode research community, there is a need for an affordable and effective way to maintain large, age-matched populations of C. elegans.

 

Here, we present a methodology for mechanically sorting and cleaning C. elegans. Our aim is to provide a cost-effective, efficient, fast, and simple process to obtain animals of uniform sizes and life stages for their use in experiments.

 

This tool, the Caenorhabditis Sieve, uses a custom-built lid system that threads onto common conical lab tubes and sorts C. elegans based on body size. We also demonstrate that the Caenorhabditis Sieve effectively transfers animals from one culture plate to another allowing for a rapid sorting, synchronizing, and cleaning without impacting markers of health, including motility and stress-inducible gene reporters. This accessible and innovative tool is a fast, efficient, and non-stressful option for maintaining C. elegans populations.

Protein Disaggregation in Multicellular Organisms.

Protein aggregates are formed in cells with profoundly perturbed proteostasis, where the generation of misfolded proteins exceeds the cellular refolding and degradative capacity. They are a hallmark of protein conformational disorders and aged and/or environmentally stressed cells.

 

Protein aggregation is a reversible process in vivo, which counteracts proteotoxicities derived from aggregate persistence, but the chaperone machineries involved in protein disaggregation in Metazoa were uncovered only recently.

 

Here we highlight recent advances in the mechanistic understanding of the major protein disaggregation machinery mediated by the Hsp70 chaperone system and discuss emerging alternative disaggregation activities in multicellular organisms.

Toxicity of silver nanoparticles, multiwalled carbon nanotubes, and dendrimers assessed with multicellular organism Caenorhabditis elegans.

Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 1010 particle/mL.

Population-based observations and gene expression analysis were employed in this study. SNP and PAMAM caused decrease in the number of live nematodes and their body length, but MWCNT did not affect the population of nematodes.

 

Gene expression analysis revealed significant changes caused by the presence of all studied nanomaterials, and the results strongly suggest a specific metabolic response of the nematode organism to exposure to various nanomaterials.

It was shown that C. elegans is a very sensitive organism capable to respond specifically to the exposure to some nanomaterials and therefore could be considered as a possible biosensor for early warning of presence of some nanoparticles.

 

 

OxiSelect Intracellular ROS Assay Kit (Green Fluorescence)

STA-342 96 assays
EUR 762
Description: The OxiSelect ROS Assay Kit is a cell-based assay for measuring hydroxyl, peroxyl, and other reactive oxygen species activity within a cell. The assay employs the cell-permeable fluorogenic probe DCFH-DA, which diffuses into cells and is deacetylcated by cellular esterases into the non-fluorescent DCFH (Figure 1). In the presence of ROS, DCFH is rapidly oxidized to highly fluorescent DCF. Fluorescence is read on a standard fluorometric plate reader.

OxiSelect Intracellular ROS Assay Kit (Green Fluorescence)

STA-342-5 5 x 96 assays
EUR 3058.8
Description: The OxiSelect ROS Assay Kit is a cell-based assay for measuring hydroxyl, peroxyl, and other reactive oxygen species activity within a cell. The assay employs the cell-permeable fluorogenic probe DCFH-DA, which diffuses into cells and is deacetylcated by cellular esterases into the non-fluorescent DCFH (Figure 1). In the presence of ROS, DCFH is rapidly oxidized to highly fluorescent DCF. Fluorescence is read on a standard fluorometric plate reader.

OxiSelect Cellular Antioxidant Assay Kit (Green Fluorescence)

STA-349 192 assays
EUR 644.4
Description: The OxiSelect Cellular Antioxidant Assay Kit is a cell-based assay for measuring the activity of an exogenous antioxidant compound within adherent cells.  Cells are first cultured in a 96-well black fluorescence cell culture plate until confluent. Then the cells are pre-incubated with a cell-permeable DCFH-DA fluorescence probe dye and the bioflavonoid Quercetin, or the antioxidant sample being tested.  After a brief incubation, the cells are washed, and the reaction started by adding the Free Radical Initiator.  The Free Radical Initiator creates free radicals that convert the probe to highly fluorescent DCF.  The Quercetin inhibits the formation of free radicals, and thus DCF formation, in a concentration dependent manner.

OxiSelect Intracellular ROS Assay Kit (Green Fluorescence), Trial Size

STA-342-T 20 assays
EUR 414
Description: The OxiSelect ROS Assay Kit is a cell-based assay for measuring hydroxyl, peroxyl, and other reactive oxygen species activity within a cell. The assay employs the cell-permeable fluorogenic probe DCFH-DA, which diffuses into cells and is deacetylcated by cellular esterases into the non-fluorescent DCFH (Figure 1). In the presence of ROS, DCFH is rapidly oxidized to highly fluorescent DCF. Fluorescence is read on a standard fluorometric plate reader.

OxiSelect In Vitro ROS/RNS Assay Kit (Green Fluorescence)

STA-347 96 assays
EUR 734.4
Description: The OxiSelect In Vitro ROS/RNS Assay provides a sensitive method to detect total reactive oxygen species (ROS) plus reactive nitrogen species (RNS) in a wide variety of sample types. This assay employs a proprietary fluorogenic probe, DCFH-DiOxyQ; the probe is primed with a dequenching reagent to the highly reactive DCFH form. In the presence of ROS and RNS, the DCFH is rapidly oxidized to the highly fluorescent DCF.

OxiSelect In Vitro ROS/RNS Assay Kit (Green Fluorescence)

STA-347-5 5 x 96 assays
EUR 2913.6
Description: The OxiSelect In Vitro ROS/RNS Assay provides a sensitive method to detect total reactive oxygen species (ROS) plus reactive nitrogen species (RNS) in a wide variety of sample types. This assay employs a proprietary fluorogenic probe, DCFH-DiOxyQ; the probe is primed with a dequenching reagent to the highly reactive DCFH form. In the presence of ROS and RNS, the DCFH is rapidly oxidized to the highly fluorescent DCF.

OxiSelect In Vitro ROS/RNS Assay Kit (Green Fluorescence), Trial Size

STA-347-T 20 assays
EUR 400.8
Description: The OxiSelect In Vitro ROS/RNS Assay provides a sensitive method to detect total reactive oxygen species (ROS) plus reactive nitrogen species (RNS) in a wide variety of sample types. This assay employs a proprietary fluorogenic probe, DCFH-DiOxyQ; the probe is primed with a dequenching reagent to the highly reactive DCFH form. In the presence of ROS and RNS, the DCFH is rapidly oxidized to the highly fluorescent DCF.

PTPN11 (Ab-580) Antibody

CSB-PA961746-
EUR 402
Description: A polyclonal antibody against PTPN11 (Ab-580). Recognizes PTPN11 (Ab-580) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

PTPN11 (Ab-580) Antibody

CSB-PA961746-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against PTPN11 (Ab-580). Recognizes PTPN11 (Ab-580) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

MemBriteâ„¢ Fix 568/580

30095 1KIT
EUR 772.8
Description: Minimum order quantity: 1 unit of 1KIT

hsa-miR-580 Primers

MPH01878 150 ul / 10 uM
EUR 145.2

SHP-2 (Ab-580) Antibody

21320-100ul 100ul
EUR 302.4

SHP-2 (Ab-580) Antibody

21320-50ul 50ul
EUR 224.4

PYK2 (Phospho-Tyr579/580) Antibody

13230-100ul 100ul
EUR 302.4

PYK2 (Phospho-Tyr579/580) Antibody

13230-50ul 50ul
EUR 224.4

anti-SHP-2 (Ab-580)

LF-PA20454 100 ul
EUR 400.8
Description: Rabbit polyclonal to SHP-2

hsa-miR-580 miRNA Inhibitor

MIH03164 2 x 5.0 nmol
EUR 211.2

hsa-miR-580-3p Primers

MPH03331 150 ul / 10 uM
EUR 145.2

hsa-miR-580-5p Primers

MPH03332 150 ul / 10 uM
EUR 145.2

hsa-miR-580 miRNA Antagomir

MNH03164 2 x 5.0 nmol
EUR 394.8

mFluor™ Blue 580 SE

1178 1 mg
EUR 318

DIPAK LONG

CPDI000L1 EACH
EUR 304.62

Serpin A1c Recombinant Protein

91-580 0.05 mg
EUR 821.4
Description: Alpha-1-antitrypsin 1-3(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.

Kallikrein 7 Recombinant Protein

92-580 0.05 mg
EUR 821.4
Description: Kallikrein7, also named as stratum corneum chymotryptic enzyme (SCCE), is a secreted protein of the Kallikrein-related peptidase (KLK) family. This family contains fifteen homologous secreted serine endopeptidases and plays a significant role in various physiological processes, including skin desquamation, semen liquefaction, neural plasticity, and body fluid homeostasis. In skin KLK5, KLK 7 and KLK14 are able to degrade corneodesmosomes, which leads to desquamation of skin surface cells. KLK activation is believed to be mediated through highly organized proteolytic cascades, regulated through a series of feedback loops, inhibitors, auto-degradation and internal cleavages. Studies have shown that one potential physiological activator for KLK7 is KLK5. Along with KLK14, these three kallikreins form a proteolytic cascade in the stratum corneum. KLK7 is primarily expressed in the skin but is also detected at relatively high levels in esophagus, heart, liver, central nervous system, kidney, pancreas, mammary and salivary glands.

Malachite green

AG060 1 mg
EUR 627.6

Leucomalachite green

AG105 1 mg
EUR 627.6

MitoView Green

70054 20X50UG
EUR 271.2
Description: Minimum order quantity: 1 unit of 20X50UG

Bromocresol green

20-abx186394
  • EUR 493.20
  • EUR 292.80
  • 100 g
  • 25 g

Brilliant green

BB0242 25g
EUR 67.31

Malachite green

AT060 1mg
EUR 2148

Leucomalachite green

AT105 1mg
EUR 1641.6

Bromocresol Green

GT4023-25G 25 g
EUR 132

Bromocresol Green

GT4023-5G 5 g
EUR 64.8

Leucomalachite Green

GT7606-10G 10 g
EUR 112.8

Leucomalachite Green

GT7606-25G 25 g
EUR 189.6

Leucomalachite Green

GT7606-5G 5 g
EUR 79.2

PYK2 (Phospho-Tyr579/580) Conjugated Antibody

C13230 100ul
EUR 476.4

Phospho-PYK2 (Tyr579/580) Blocking Peptide

AF7383-BP 1mg
EUR 234

Mesothelin / MSLN (296-580) Recombinant Protein

11-216 0.1 mg
EUR 714.3
Description: Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

MemBriteâ„¢ Fix 568/580, Trial Size

30095-T 1KIT
EUR 266.4
Description: Minimum order quantity: 1 unit of 1KIT

DAX-J2™ Ratio 580/460

16310 1 mg
EUR 471.6

Zinc Finger Protein 580 (ZNF580) Antibody

abx030431-400ul 400 ul
EUR 627.6

Zinc Finger Protein 580 (ZNF580) Antibody

abx030431-80l 80 µl
EUR 343.2

Recombinant human Zinc finger protein 580

P2142 100ug Ask for price
Description: Recombinant protein for human Zinc finger protein 580

hsa-miR-580-3p miRNA Inhibitor

MIH03165 2 x 5.0 nmol
EUR 211.2

hsa-miR-580-5p miRNA Inhibitor

MIH03166 2 x 5.0 nmol
EUR 211.2

hsa-miR-580-3p miRNA Antagomir

MNH03165 2 x 5.0 nmol
EUR 394.8

hsa-miR-580-5p miRNA Antagomir

MNH03166 2 x 5.0 nmol
EUR 394.8

CoolCell LX. green Cell Freezing Container

432002 EACH
EUR 206.34

Long trebler phosphoramidite

A8151-250 250 mg
EUR 408
Description: Long trebler phosphoramidite is a branching reagent for oligonucleotide synthesis allowing to synthesize branched DNA structures using standard DNA synthesizer.

Wick 100mm Long

BUR4508 PK10
EUR 6.27

CytoFix™ BCECF, AM *Optimized for long term cellular pH tracking*

21200 1 mg
EUR 318

Green Fluorescent Protein

CH22124 100 ul of 1 mg/ml
EUR 522

Malachite Green [HRP]

DAGA-073H 1mg
EUR 1404

Leucomalachite Green [HRP]

DAGA-074H 1mg
EUR 1326

Malachite Green [BSA]

DAGA-085B 1mg
EUR 936

Leucomalachite Green [BSA]

DAGA-086B 1mg
EUR 936

Malachite Green [KLH]

DAGA-091K 1mg
EUR 1326

Leucomalachite Green [KLH]

DAGA-092K 1mg
EUR 1170

DNASE & METHYL GREEN

D04-102-10kg 10 kg
EUR 11270.4

DNASE & METHYL GREEN

D04-102-2kg 2kg
EUR 2497.2

DNASE & METHYL GREEN

D04-102-500g 500 g
EUR 722.4

Leuco- Malachiet green

AG131 1 mg
EUR 627.6

Fast Green FCF

FB0452 5g
EUR 66.26

Fast Green Solution

FGN125 125 ml
EUR 79.2

Fast Green Solution

FGN500 500 ml
EUR 115.2

Fast Green Solution

FGN999 1000 ml
EUR 148.8

Malachite green Antibody

48363-100ul 100ul
EUR 399.6

Malachite green Antibody

48363-50ul 50ul
EUR 286.8

Thiolite™ Green

21508 5 mg
EUR 367.2

BactoViewâ„¢ Live Green

40102 100uL
EUR 384
Description: Minimum order quantity: 1 unit of 100uL



Leave a Reply

Your email address will not be published.