To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Pore-forming proteins (PFPs) are current in all domains of life, and play an essential function in host-pathogen warfare and within the elimination of cancers. They are often employed to ship particular effectors throughout membranes, to disrupt membrane integrity interfering with cell homeostasis, and to lyse membranes both destroying intracellular organelles or whole cells. Contemplating the harmful potential of PFPs, it’s maybe not stunning that mechanisms controlling their exercise are remarkably advanced, particularly in multicellular organisms. Mammalian PFPs found up to now embody the complement membrane assault advanced (MAC), perforins, in addition to gasdermins.

Whereas the first operate of perforin-1 and gasdermins is to get rid of contaminated or cancerous host cells, perforin-2 and MAC can goal pathogens straight. But, all mammalian PFPs are in precept able to producing pores in membranes of wholesome host cells which-if uncontrolled-could have dire, and doubtlessly deadly penalties. On this overview, we’ll spotlight the methods employed to guard the host from destruction by endogenous PFPs, whereas enabling well timed and environment friendly elimination of goal cells. The nuclear lamina-a meshwork of intermediate filaments termed lamins-is primarily accountable for the mechanical stability of the nucleus in multicellular organisms. Nonetheless, structural-mechanical characterization of lamin filaments assembled in situ stays elusive.

Right here, we apply an integrative method combining atomic pressure microscopy, cryo-electron tomography, community evaluation, and molecular dynamics simulations to straight measure the mechanical response of single lamin filaments in three-dimensional meshwork. Endogenous lamin filaments painting non-Hookean conduct – they deform reversibly at a number of hundred picoNewtons and stiffen at nanoNewton forces.

 

Comparative Evaluation of ROS Community Genes in Extremophile Eukaryotes

The reactive oxygen species (ROS) gene community, consisting of each ROS-generating and detoxifying enzymes, adjusts ROS ranges in response to numerous stimuli. We carried out a cross-kingdom comparability of ROS gene networks to research how they’ve developed throughout all Eukaryotes, together with protists, fungi, vegetation and animals. We included the genomes of 16 extremotolerant Eukaryotes to realize perception into ROS gene evolution in organisms that have excessive stress circumstances. Our evaluation targeted on ROS genes present in all Eukaryotes (corresponding to catalases, superoxide dismutases, glutathione reductases, peroxidases and glutathione peroxidase/peroxiredoxins) in addition to these particular to sure teams, corresponding to ascorbate peroxidases, dehydroascorbate/monodehydroascorbate reductases in vegetation and different photosynthetic organisms.
ROS-producing NADPH oxidases (NOX) had been present in most multicellular organisms, though a number of NOX-like genes had been recognized in unicellular or filamentous species. Nonetheless, regardless of the intense circumstances skilled by extremophile species, we discovered no proof for growth of ROS-related gene households in these species in comparison with different Eukaryotes. Tardigrades and rotifers do present ROS gene expansions that may very well be associated to their excessive existence, though a excessive charge of lineage-specific horizontal gene switch occasions, coupled with current tetraploidy in rotifers, may clarify this commentary. This implies that the basal Eukaryotic ROS scavenging techniques are adequate to take care of ROS homeostasis even beneath essentially the most excessive circumstances. The MOB household proteins are constituted by extremely conserved eukaryote kinase sign adaptors which are usually important each for cell and organism survival.
Traditionally, MOB household proteins have been described as kinase activators taking part in Hippo and Mitotic Exit Community/ Septation Initiation Community (MEN/SIN) signaling pathways which have central roles in regulating cytokinesis, cell polarity, cell proliferation and cell destiny to manage organ progress and regeneration. In metazoans, MOB proteins act as central sign adaptors of the core kinase module MST1/2, LATS1/2, and NDR1/2 kinases that phosphorylate the YAP/TAZ transcriptional co-activators, effectors of the Hippo signaling pathway.
To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins
To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Symbiotic Origin of Apoptosis

The progress of evolutionary biology has revealed that symbiosis performed a primary function within the evolution of advanced eukaryotic organisms, together with people. Mitochondria are literally simplified endosymbiotic micro organism presently enjoying the function of mobile organelles. Mitochondrial domestication occurred on the very starting of eukaryotic evolution. Mitochondria have two totally different primary features: they produce vitality utilizing oxidative respiration, and so they provoke totally different types of apoptotic programmed/regulated cell dying.
Apoptotic programmed cell dying might have totally different cytological varieties. Mechanisms of apoptotic programmed cell dying exist even within the unicellular organisms, and so they play a primary function within the improvement of advanced multicellular organisms, corresponding to fungi, inexperienced vegetation, and animals. Multicellularity was independently established many occasions amongst eukaryotes. There are indications that apoptotic programmed cell dying is a trait required for the institution of multicellularity. Regulated cell dying is initiated by many alternative parallel biochemical pathways. It’s usually accepted that apoptosis developed throughout mitochondrial domestication.

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx241949
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx242196
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx327509
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

abx412464-01mg 0.1 mg
EUR 610.8

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx213618
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx213619
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (HRP)

20-abx303073
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (FITC)

20-abx303074
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (Biotin)

20-abx303075
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human apoptosis protease activating factor- 1 ELISA Kit

ELA-E1054h 96 Tests
EUR 988.8

Mouse apoptosis protease activating factor- 1 ELISA Kit

ELA-E1054m 96 Tests
EUR 1038

Human apoptosis protease activating factor-1, Apaf-1 ELISA Kit

1-CSB-E08996h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human apoptosis protease activating factor-1, Apaf-1 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx054561-96tests 96 tests
EUR 943.2

Human Apoptosis Protease Activating Factor 1 (APAF1) CLIA Kit

abx196456-96tests 96 tests
EUR 990

Monkey Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx358759-96tests 96 tests
EUR 990

Rabbit Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx363578-96tests 96 tests
EUR 990

Pig Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx360758-96tests 96 tests
EUR 990

Human Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx252034-96tests 96 tests
EUR 848.4

Chicken Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx355615-96tests 96 tests
EUR 990

Human apoptosis protease activating factor-1,ICAD ELISA Kit

CN-03380H1 96T
EUR 523.2

Human apoptosis protease activating factor-1,ICAD ELISA Kit

CN-03380H2 48T
EUR 344.4

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit

EH2654 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human apoptosis protease activating factor-1,Apaf-1 ELISA Kit

201-12-1836 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human apoptosis protease activating factor-1, Apaf-1 ELISA Kit

CSB-E08996h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human apoptosis protease activating factor-1, Apaf-1 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

GA-E1852HM-48T 48T
EUR 346.8

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

GA-E1852HM-96T 96T
EUR 559.2

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

QY-E03796 96T
EUR 472.8

CLIA kit for Human APAF1 (Apoptosis Protease Activating Factor 1)

E-CL-H0393 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human APAF1 (Apoptosis Protease Activating Factor 1)

E-EL-H0481 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse APAF1 (Apoptosis Protease Activating Factor 1)

E-EL-M0143 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

Human Apaf-1 (Apoptosis Protease Activating Factor-1) Control/blocking peptide

APAF11-P 100 ug
EUR 196.8

Human Apoptotic protease-activating factor 1 (APAF1)

1-CSB-YP001885HU
  • EUR 703.20
  • EUR 358.80
  • EUR 2606.40
  • EUR 1080.00
  • EUR 1730.40
  • EUR 458.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Apoptotic protease-activating factor 1(APAF1),partial expressed in Yeast

Rabbit Anti-HumanApaf-1 (Apoptosis Protease Activating Factor-1) IgG, aff pure

APAF11-A 100 ug
EUR 578.4

Protease Inhibitor Cocktail 

R-1101
  • EUR 176.58
  • EUR 79.20
  • 1 ml
  • 1 ml

Apoptotic Protease-Activating Factor 1 (APAF-1) Antibody

20-abx009588
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Apoptotic Protease-Activating Factor 1 (APAF-1) Antibody

20-abx121271
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Apoptotic Protease-Activating Factor 1 (APAF-1-ALT) Antibody

20-abx013022
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Rat Apaf1/ Apoptotic protease-activating factor 1 ELISA Kit

E0077Ra 1 Kit
EUR 775.2

Mouse Apaf1/ Apoptotic protease-activating factor 1 ELISA Kit

E0107Mo 1 Kit
EUR 685.2

Rat Apaf1(Apoptotic protease-activating factor 1) ELISA Kit

ER0427 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

ELISA kit for Rat Apoptotic protease-activating factor 1

EK2658 96 tests
EUR 865.2
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Apoptotic protease-activating factor 1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Apoptotic protease- activating factor 1, APAF1 ELISA KIT

ELI-03414h 96 Tests
EUR 988.8

Mouse Apoptotic protease- activating factor 1, Apaf1 ELISA KIT

ELI-03416m 96 Tests
EUR 1038

Recombinant Transmembrane Protease Serine 2 Protein, Partial

E80016
  • EUR 470.80
  • EUR 753.50
  • EUR 1824.90
  • 20 ul
  • 100 ul
  • 500 ul

Channel Activating Protease 1 (CAP1) Antibody

20-abx171674
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Channel Activating Protease 1 (CAP1) Antibody

20-abx111356
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Channel Activating Protease 1 (CAP1) Antibody

20-abx214652
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Channel Activating Protease 1 (CAP1) Antibody

20-abx214653
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Apaf1 ELISA Kit| Rat Apoptotic protease-activating factor 1 ELIS

EF017272 96 Tests
EUR 826.8

Human ICE protease-activating factor,IRAP ELISA Kit

201-12-0672 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human ICE protease-activating factor,IRAP ELISA Kit

CN-04462H1 96T
EUR 546

Human ICE protease-activating factor,IRAP ELISA Kit

CN-04462H2 48T
EUR 364.8

Human ICE protease-activating factor(IRAP)ELISA Kit

GA-E0688HM-48T 48T
EUR 346.8

Human ICE protease-activating factor(IRAP)ELISA Kit

GA-E0688HM-96T 96T
EUR 559.2

Human ICE protease-activating factor(IRAP)ELISA Kit

QY-E04867 96T
EUR 433.2

Lethal factor Protease Substrate 1, Internally quenched Coumarin peptide substrate for monitoring LF protease activity (19aa)

LFPS-1 500 ug
EUR 634.8

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-100ug

QP8984-ye-100ug 100ug
EUR 804

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-10ug

QP8984-ye-10ug 10ug
EUR 369.6

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-1mg

QP8984-ye-1mg 1mg
EUR 3296.4

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-200ug

QP8984-ye-200ug 200ug
EUR 1282.8

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-500ug

QP8984-ye-500ug 500ug
EUR 2164.8

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-50ug

QP8984-ye-50ug 50ug
EUR 500.4

Channel Activating Protease 1 (CAP1) Antibody (FITC)

20-abx271303
  • EUR 610.80
  • EUR 309.60
  • EUR 1830.00
  • EUR 844.80
  • EUR 493.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Channel Activating Protease 1 (CAP1) Antibody (Biotin)

20-abx271569
  • EUR 577.20
  • EUR 292.80
  • EUR 1696.80
  • EUR 794.40
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

ELISA kit for Human ICE protease-activating factor (IRAP)

KTE62551-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human ICE protease-activating factor (IRAP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human ICE protease-activating factor (IRAP)

KTE62551-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human ICE protease-activating factor (IRAP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human ICE protease-activating factor (IRAP)

KTE62551-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human ICE protease-activating factor (IRAP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

BAFF B-cell Activating Factor Human Recombinant Protein

PROTQ9Y275-1 Regular: 20ug
EUR 380.4
Description: BAFF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton. ;The BAFF is purified by proprietary chromatographic techniques.

EZCut? SUMO Protease 1 Agarose Beads

M1028-1
EUR 288

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

4-SEG321Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Channel Activating Protease 1 (CAP1) in samples from Serum, plasma, urine and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Apoptosis-inducing factor 1, mitochondrial (AIFM1)

1-CSB-EP001492HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Apoptosis-inducing factor 1, mitochondrial(AIFM1),partial expressed in E.coli

Protease-Activated Receptor-2 Activating Peptide

HY-P1308 10mM/1mL
EUR 439.2

TurboTEV Protease, Recombinant

9205-1
EUR 738

Apoptosis-Inducing Factor

PR27201 5 ug
EUR 229.2

Human ice Protease-Activating Factor (IPAF) or CARD12 Control/blocking peptide

IPAF11-P 100 ug
EUR 196.8

Rabbit Anti-Human Ice Protease-Activating Factor (IPAF) or CARD12 antiserum

IPAF11-S 100 ul
EUR 548.4

ELISA kit for Human CAP1 (Channel Activating Protease 1)

ELK3115 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Channel Activating Protease 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human CAP1 (Channel Activating Protease 1)

ELK5109 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Channel Activating Protease 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Nuclear Apoptosis Inducing Factor 1 Protein

20-abx263420
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

DiscoveryProbe? Apoptosis Compound Library

L1036-.1 100 uL/well(10 mM solution)
EUR 4166.4

Turbo3C (HRV3C) Protease, Recombinant

9206-1
EUR 561.6

DiscoveryProbe? Protease Inhibitor Library

L1035-.1 100 uL/well(10 mM solution)
EUR 4068

Activating Transcription Factor 1 Recombinant Protein

92-277 0.05 mg
EUR 821.4
Description: Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the Tax-responsive element (TRE) of HTLV-I. ATF1 mediates PKA-induced stimulation of CRE-reporter genes, represses the expression of FTH1 and other antioxidant detoxification genes, triggers cell proliferation and transformation. ATF1 is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and CDK3. Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Activating Transcription Factor 1 (ATF1) Antibody

abx148385-100ug 100 ug
EUR 526.8

Activating Transcription Factor-1 Protein (Recombinant)

20-abx073863
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Activating Transcription Factor 1 (ATF1) Antibody

20-abx103391
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

20-abx103392
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

abx038463-100ug 100 ug
EUR 469.2

Activating Transcription Factor 1 (ATF1) Antibody

20-abx004436
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx009565
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx110784
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx131007
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

20-abx013416
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Activating Transcription Factor 1 (ATF1) Antibody

20-abx322143
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx329224
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

abx332273-100ul 100 ul
EUR 510

Activating Transcription Factor 1 (ATF1) Antibody

abx230659-100ug 100 ug
EUR 610.8

Activating Transcription Factor 1 (ATF1) Antibody

20-abx325979
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

abx432374-200ul 200 ul
EUR 460.8

Activating Transcription Factor 1 (ATF1) Antibody

20-abx212729
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx212730
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Recombinant Activating Transcription Factor 1 (ATF1)

4-RPB346Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Activating Transcription Factor 1 expressed in: E.coli

Recombinant Activating Transcription Factor 1 (ATF1)

4-RPB346Mu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Activating Transcription Factor 1 expressed in: E.coli

Recombinant Activating Transcription Factor 1 (ATF1)

4-RPB346Ra01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Activating Transcription Factor 1 expressed in: E.coli

Protease Inhibitor Cocktail 

R-1101-1 1 ml
EUR 79.2

Human Membrane-bound transcription factor site-1 protease (MBTPS1)

1-CSB-EP617930HU
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Membrane-bound transcription factor site-1 protease(MBTPS1),partial expressed in E.coli

ubiquitin specific protease 3 fragment

A1097-1 1 mg
EUR 129.6
Description: The ubiquitin speci?c protease 3 USP3 is a deubiquitinating enzyme for uH2A and uH2B. USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo.

EZBlock? Protease Inhibitor Cocktail XV

K393-1
EUR 183.6

EZBlock? Protease Inhibitor Cocktail IV

K279-1
EUR 138

EZBlock? Protease Inhibitor Cocktail XIV

K223-1
EUR 157.2

EZBlock? Protease Inhibitor Cocktail VII

K292-1
EUR 151.2

EZBlock? Protease Inhibitor Cocktail VIII

K293-1
EUR 151.2

EZBlock? Protease Inhibitor Cocktail IX

K294-1
EUR 151.2

EZBlock? Protease Inhibitor Cocktail XVI

S233-1
EUR 157.2
Nonetheless, there are totally different hypothetical fashions of the origin of apoptosis. The phylogenetic research of my group point out that apoptosis most likely developed throughout an evolutionary arms race between host ancestral eukaryotic predators and ancestral prey mitochondria (named protomitochondria). Protomitochondrial prey produced many alternative toxins as a protection in opposition to predators. From these toxins developed extant apoptotic components. There are indications that cardio respiration and apoptosis co-evolved and are functionally linked in extant organisms. Perturbations of apoptosis and oxidative respiration are ceaselessly noticed throughout neoplastic transition. Our group confirmed that perturbations of apoptosis in yeasts additionally trigger perturbations of oxidative respiration.

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