To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Pore-forming proteins (PFPs) are current in all domains of life, and play an essential function in host-pathogen warfare and within the elimination of cancers. They are often employed to ship particular effectors throughout membranes, to disrupt membrane integrity interfering with cell homeostasis, and to lyse membranes both destroying intracellular organelles or whole cells. Contemplating the harmful potential of PFPs, it’s maybe not stunning that mechanisms controlling their exercise are remarkably advanced, particularly in multicellular organisms. Mammalian PFPs found up to now embody the complement membrane assault advanced (MAC), perforins, in addition to gasdermins.

Whereas the first operate of perforin-1 and gasdermins is to get rid of contaminated or cancerous host cells, perforin-2 and MAC can goal pathogens straight. But, all mammalian PFPs are in precept able to producing pores in membranes of wholesome host cells which-if uncontrolled-could have dire, and doubtlessly deadly penalties. On this overview, we’ll spotlight the methods employed to guard the host from destruction by endogenous PFPs, whereas enabling well timed and environment friendly elimination of goal cells. The nuclear lamina-a meshwork of intermediate filaments termed lamins-is primarily accountable for the mechanical stability of the nucleus in multicellular organisms. Nonetheless, structural-mechanical characterization of lamin filaments assembled in situ stays elusive.

Right here, we apply an integrative method combining atomic pressure microscopy, cryo-electron tomography, community evaluation, and molecular dynamics simulations to straight measure the mechanical response of single lamin filaments in three-dimensional meshwork. Endogenous lamin filaments painting non-Hookean conduct – they deform reversibly at a number of hundred picoNewtons and stiffen at nanoNewton forces.

 

Comparative Evaluation of ROS Community Genes in Extremophile Eukaryotes

The reactive oxygen species (ROS) gene community, consisting of each ROS-generating and detoxifying enzymes, adjusts ROS ranges in response to numerous stimuli. We carried out a cross-kingdom comparability of ROS gene networks to research how they’ve developed throughout all Eukaryotes, together with protists, fungi, vegetation and animals. We included the genomes of 16 extremotolerant Eukaryotes to realize perception into ROS gene evolution in organisms that have excessive stress circumstances. Our evaluation targeted on ROS genes present in all Eukaryotes (corresponding to catalases, superoxide dismutases, glutathione reductases, peroxidases and glutathione peroxidase/peroxiredoxins) in addition to these particular to sure teams, corresponding to ascorbate peroxidases, dehydroascorbate/monodehydroascorbate reductases in vegetation and different photosynthetic organisms.
ROS-producing NADPH oxidases (NOX) had been present in most multicellular organisms, though a number of NOX-like genes had been recognized in unicellular or filamentous species. Nonetheless, regardless of the intense circumstances skilled by extremophile species, we discovered no proof for growth of ROS-related gene households in these species in comparison with different Eukaryotes. Tardigrades and rotifers do present ROS gene expansions that may very well be associated to their excessive existence, though a excessive charge of lineage-specific horizontal gene switch occasions, coupled with current tetraploidy in rotifers, may clarify this commentary. This implies that the basal Eukaryotic ROS scavenging techniques are adequate to take care of ROS homeostasis even beneath essentially the most excessive circumstances. The MOB household proteins are constituted by extremely conserved eukaryote kinase sign adaptors which are usually important each for cell and organism survival.
Traditionally, MOB household proteins have been described as kinase activators taking part in Hippo and Mitotic Exit Community/ Septation Initiation Community (MEN/SIN) signaling pathways which have central roles in regulating cytokinesis, cell polarity, cell proliferation and cell destiny to manage organ progress and regeneration. In metazoans, MOB proteins act as central sign adaptors of the core kinase module MST1/2, LATS1/2, and NDR1/2 kinases that phosphorylate the YAP/TAZ transcriptional co-activators, effectors of the Hippo signaling pathway.
To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins
To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Symbiotic Origin of Apoptosis

The progress of evolutionary biology has revealed that symbiosis performed a primary function within the evolution of advanced eukaryotic organisms, together with people. Mitochondria are literally simplified endosymbiotic micro organism presently enjoying the function of mobile organelles. Mitochondrial domestication occurred on the very starting of eukaryotic evolution. Mitochondria have two totally different primary features: they produce vitality utilizing oxidative respiration, and so they provoke totally different types of apoptotic programmed/regulated cell dying.
Apoptotic programmed cell dying might have totally different cytological varieties. Mechanisms of apoptotic programmed cell dying exist even within the unicellular organisms, and so they play a primary function within the improvement of advanced multicellular organisms, corresponding to fungi, inexperienced vegetation, and animals. Multicellularity was independently established many occasions amongst eukaryotes. There are indications that apoptotic programmed cell dying is a trait required for the institution of multicellularity. Regulated cell dying is initiated by many alternative parallel biochemical pathways. It’s usually accepted that apoptosis developed throughout mitochondrial domestication.

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

abx412464-01mg 0.1 mg
EUR 610.8

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

abx330689-100ul 100 ul
EUR 510

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx327509
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx111035
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

abx037673-100ug 100 ug
EUR 469.2

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx301131
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human apoptosis protease activating factor- 1 ELISA Kit

ELA-E1054h 96 Tests
EUR 988.8

Mouse apoptosis protease activating factor- 1 ELISA Kit

ELA-E1054m 96 Tests
EUR 1038

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (HRP)

20-abx303073
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (FITC)

20-abx303074
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rat Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL0759r 96 Tests
EUR 498

Goat Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL0595Gt 96T
EUR 528

Pig Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx360758-96tests 96 tests
EUR 990

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (Biotin)

20-abx303075
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human apoptosis protease activating factor-1,ICAD ELISA Kit

CN-03380H1 96T
EUR 523.2

Human apoptosis protease activating factor-1,ICAD ELISA Kit

CN-03380H2 48T
EUR 344.4

Human Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL0855Hu 96 wells
EUR 468

Rat Apoptosis Protease Activating Factor-1,Apaf-1 ELISA Kit

SL1576Ra - Ask for price

Human Apoptosis Protease Activating Factor 1 (APAF1) CLIA Kit

abx196456-96tests 96 tests
EUR 990

Canine Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL1917Ca 2012 wells
EUR 528

Bovine Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL1975Bo 96 T
EUR 528

Human Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx252034-96tests 96 tests
EUR 848.4

Human Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx054561-96tests 96 tests
EUR 943.2

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit

EH2654 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit

EKF60576-48T 48T
EUR 396.9

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit

EKF60576-5x96T 5x96T
EUR 2693.25

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit

EKF60576-96T 96T
EUR 567

Human APAF1 (Apoptosis Protease Activating Factor 1) ELISA Kit

EKE60335-5x96T 5x96T
EUR 3124.08

Human APAF1 (Apoptosis Protease Activating Factor 1) ELISA Kit

EKE60335-96T 96T
EUR 657.7

Chicken Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL0651Ch 746 T
EUR 528

Porcine Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL0499Po 96T
EUR 528

Human apoptosis protease activating factor-1,Apaf-1 ELISA Kit

201-12-1836 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human apoptosis protease activating factor-1, Apaf-1 ELISA Kit

CSB-E08996h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human apoptosis protease activating factor-1, Apaf-1 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human apoptosis protease activating factor-1, Apaf-1 ELISA Kit

1-CSB-E08996h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human apoptosis protease activating factor-1, Apaf-1 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

GA-E1852HM-48T 48T
EUR 346.8

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

GA-E1852HM-96T 96T
EUR 559.2

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

QY-E03796 96T
EUR 472.8

Human apoptosis protease activating factor-1,Apaf-1 ELISA Kit

YLA0089HU-48T 48T
EUR 435

Human apoptosis protease activating factor-1,Apaf-1 ELISA Kit

YLA0089HU-96T 96T
EUR 562.5

Human apoptosis protease activating factor-1,Apaf-1 ELISA Kit

SL0290Hu 96 Tests
EUR 468

Monkey Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx358759-96tests 96 tests
EUR 990

Rabbit Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx363578-96tests 96 tests
EUR 990

Chicken Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx355615-96tests 96 tests
EUR 990

CLIA kit for Human APAF1 (Apoptosis Protease Activating Factor 1)

E-CL-H0393 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Guinea pig Apoptosis protease activating factor-1(ICAD) ELISA Kit

NSL0671Gp 96T
EUR 528

ELISA kit for Mouse APAF1 (Apoptosis Protease Activating Factor 1)

E-EL-M0143 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human APAF1 (Apoptosis Protease Activating Factor 1)

E-EL-H0481 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

Human Apaf-1 (Apoptosis Protease Activating Factor-1) Control/blocking peptide

APAF11-P 100 ug
EUR 196.8

Rabbit Anti-HumanApaf-1 (Apoptosis Protease Activating Factor-1) IgG, aff pure

APAF11-A 100 ug
EUR 578.4

Rat Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL0758r 96 Tests
EUR 498

Goat Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL1138Gt 96T
EUR 528

Human Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL0852Hu 96 wells
EUR 468

Mouse Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL1649m 96 Test
EUR 528

Human Apoptotic protease- activating factor 1, APAF1 ELISA KIT

ELI-03414h 96 Tests
EUR 988.8

Mouse Apoptotic protease- activating factor 1, Apaf1 ELISA KIT

ELI-03416m 96 Tests
EUR 1038

Canine Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL1792Ca 1887 wells
EUR 528

Bovine Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL1978Bo 96 T
EUR 528

Chicken Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL1163Ch 1258 T
EUR 528

Porcine Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL0956Po 96T
EUR 528

Guinea pig Apoptotic protease activating factor-1(APAF-1) ELISA Kit

NSL1212Gp 96T
EUR 528

Rat Apoptotic Peptidase Activating Factor 1 (APAF1) Protein

20-abx652562
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Apoptotic Peptidase Activating Factor 1 (APAF1) Protein

20-abx065445
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Apoptotic Peptidase Activating Factor 1 (APAF1) Protein

20-abx166657
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Apoptotic Peptidase Activating Factor 1 ELISA kit

E02A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptotic Peptidase Activating Factor 1 ELISA kit

E02A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptotic Peptidase Activating Factor 1 ELISA kit

E02A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Apoptotic Peptidase Activating Factor 1 ELISA kit

E07A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Apoptotic Peptidase Activating Factor 1 ELISA kit

E07A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Apoptotic Peptidase Activating Factor 1 ELISA kit

E07A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Apoptotic Peptidase Activating Factor 1 ELISA kit

E08A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Apoptotic Peptidase Activating Factor 1 ELISA kit

E08A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Apoptotic Peptidase Activating Factor 1 ELISA kit

E08A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptotic Peptidase Activating Factor 1 ELISA Kit

IRTAPAF1KT each
EUR 754
Description: Rat Apoptotic Peptidase Activating Factor 1 ELISA Kit

Apoptotic Peptidase Activating Factor 1 (APAF1) Antibody

20-abx104102
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Apoptotic Peptidase Activating Factor 1 (APAF1) Antibody

20-abx175444
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Apoptotic Peptidase Activating Factor 1 (APAF1) Antibody

20-abx175445
  • EUR 1496.40
  • EUR 710.40
  • 1 mg
  • 200 ug

Apoptotic Peptidase Activating Factor 1 (APAF1) Antibody

20-abx171297
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Apoptotic Peptidase Activating Factor 1 (APAF1) Antibody

20-abx171298
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Apoptotic Peptidase Activating Factor 1 (APAF1) Antibody

20-abx128750
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Goat Apoptotic Peptidase Activating Factor 1 ELISA kit

E06A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Apoptotic Peptidase Activating Factor 1 ELISA kit

E06A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Apoptotic Peptidase Activating Factor 1 ELISA kit

E06A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apoptotic Peptidase Activating Factor 1 ELISA kit

E03A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apoptotic Peptidase Activating Factor 1 ELISA kit

E03A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apoptotic Peptidase Activating Factor 1 ELISA kit

E03A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptotic Peptidase Activating Factor 1 ELISA kit

E01A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptotic Peptidase Activating Factor 1 ELISA kit

E01A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptotic Peptidase Activating Factor 1 ELISA kit

E01A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptotic Peptidase Activating Factor 1 ELISA Kit

IHUAPAF1KT each
EUR 700
Description: Human Apoptotic Peptidase Activating Factor 1 ELISA Kit

Mouse Apoptotic Peptidase Activating Factor 1 ELISA Kit

IMSAPAF1KT each
EUR 718
Description: Mouse Apoptotic Peptidase Activating Factor 1 ELISA Kit

Monkey Apoptotic Peptidase Activating Factor 1 ELISA kit

E09A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Apoptotic Peptidase Activating Factor 1 ELISA kit

E09A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Apoptotic Peptidase Activating Factor 1 ELISA kit

E09A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Apoptotic Peptidase Activating Factor 1 ELISA kit

E04A0629-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Apoptotic Peptidase Activating Factor 1 ELISA kit

E04A0629-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Apoptotic Peptidase Activating Factor 1 ELISA kit

E04A0629-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Apoptotic Peptidase Activating Factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

4-RPB054Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Apoptotic Peptidase Activating Factor 1 expressed in: E.coli

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

4-RPB054Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Apoptotic Peptidase Activating Factor 1 expressed in: E.coli

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU40373-100ug 100ug
EUR 554.4

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU40373-1mg 1mg
EUR 2457

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU40373-50ug 50ug
EUR 445.5

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU52035-100ug 100ug
EUR 517

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU52035-1mg 1mg
EUR 2293.2

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU52035-50ug 50ug
EUR 415.8

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU56879-100ug 100ug
EUR 470.4

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU56879-1mg 1mg
EUR 2184

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU56879-50ug 50ug
EUR 385

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU56880-100ug 100ug
EUR 470.4

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU56880-1mg 1mg
EUR 2184

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1)

RPU56880-50ug 50ug
EUR 385

Rat Apoptotic Peptidase Activating Factor 1 (APAF1) CLIA Kit

20-abx190686
  • EUR 10131.60
  • EUR 5396.40
  • EUR 1243.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Apoptotic Peptidase Activating Factor 1 (APAF1)CLIA Kit

SCB054Ra-10x96wellstestplate 10x96-wells test plate
EUR 7342.85
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Apoptotic Peptidase Activating Factor 1 (APAF1) in Tissue homogenates and other biological fluids.

Rat Apoptotic Peptidase Activating Factor 1 (APAF1)CLIA Kit

SCB054Ra-1x48wellstestplate 1x48-wells test plate
EUR 709.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Apoptotic Peptidase Activating Factor 1 (APAF1) in Tissue homogenates and other biological fluids.

Rat Apoptotic Peptidase Activating Factor 1 (APAF1)CLIA Kit

SCB054Ra-1x96wellstestplate 1x96-wells test plate
EUR 962.69
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Apoptotic Peptidase Activating Factor 1 (APAF1) in Tissue homogenates and other biological fluids.

Rat Apoptotic Peptidase Activating Factor 1 (APAF1)CLIA Kit

SCB054Ra-5x96wellstestplate 5x96-wells test plate
EUR 3972.1
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Apoptotic Peptidase Activating Factor 1 (APAF1) in Tissue homogenates and other biological fluids.

Rat Apoptotic Peptidase Activating Factor 1 (APAF1) CLIA Kit

4-SCB054Ra
  • EUR 7404.00
  • EUR 3973.20
  • EUR 963.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rat Apoptotic Peptidase Activating Factor 1 (APAF1)Tissue homogenates and other biological fluids

Rat Apoptotic Peptidase Activating Factor 1 (APAF1) CLIA Kit

EKU09658-48T 48T
EUR 724.22

Rat Apoptotic Peptidase Activating Factor 1 (APAF1) CLIA Kit

EKU09658-5x96T 5x96T
EUR 4914.35
Nonetheless, there are totally different hypothetical fashions of the origin of apoptosis. The phylogenetic research of my group point out that apoptosis most likely developed throughout an evolutionary arms race between host ancestral eukaryotic predators and ancestral prey mitochondria (named protomitochondria). Protomitochondrial prey produced many alternative toxins as a protection in opposition to predators. From these toxins developed extant apoptotic components. There are indications that cardio respiration and apoptosis co-evolved and are functionally linked in extant organisms. Perturbations of apoptosis and oxidative respiration are ceaselessly noticed throughout neoplastic transition. Our group confirmed that perturbations of apoptosis in yeasts additionally trigger perturbations of oxidative respiration.

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