To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Pore-forming proteins (PFPs) are current in all domains of life, and play an essential function in host-pathogen warfare and within the elimination of cancers. They are often employed to ship particular effectors throughout membranes, to disrupt membrane integrity interfering with cell homeostasis, and to lyse membranes both destroying intracellular organelles or whole cells. Contemplating the harmful potential of PFPs, it’s maybe not stunning that mechanisms controlling their exercise are remarkably advanced, particularly in multicellular organisms. Mammalian PFPs found up to now embody the complement membrane assault advanced (MAC), perforins, in addition to gasdermins.

Whereas the first operate of perforin-1 and gasdermins is to get rid of contaminated or cancerous host cells, perforin-2 and MAC can goal pathogens straight. But, all mammalian PFPs are in precept able to producing pores in membranes of wholesome host cells which-if uncontrolled-could have dire, and doubtlessly deadly penalties. On this overview, we’ll spotlight the methods employed to guard the host from destruction by endogenous PFPs, whereas enabling well timed and environment friendly elimination of goal cells. The nuclear lamina-a meshwork of intermediate filaments termed lamins-is primarily accountable for the mechanical stability of the nucleus in multicellular organisms. Nonetheless, structural-mechanical characterization of lamin filaments assembled in situ stays elusive.

Right here, we apply an integrative method combining atomic pressure microscopy, cryo-electron tomography, community evaluation, and molecular dynamics simulations to straight measure the mechanical response of single lamin filaments in three-dimensional meshwork. Endogenous lamin filaments painting non-Hookean conduct – they deform reversibly at a number of hundred picoNewtons and stiffen at nanoNewton forces.

 

Comparative Evaluation of ROS Community Genes in Extremophile Eukaryotes

The reactive oxygen species (ROS) gene community, consisting of each ROS-generating and detoxifying enzymes, adjusts ROS ranges in response to numerous stimuli. We carried out a cross-kingdom comparability of ROS gene networks to research how they’ve developed throughout all Eukaryotes, together with protists, fungi, vegetation and animals. We included the genomes of 16 extremotolerant Eukaryotes to realize perception into ROS gene evolution in organisms that have excessive stress circumstances. Our evaluation targeted on ROS genes present in all Eukaryotes (corresponding to catalases, superoxide dismutases, glutathione reductases, peroxidases and glutathione peroxidase/peroxiredoxins) in addition to these particular to sure teams, corresponding to ascorbate peroxidases, dehydroascorbate/monodehydroascorbate reductases in vegetation and different photosynthetic organisms.
ROS-producing NADPH oxidases (NOX) had been present in most multicellular organisms, though a number of NOX-like genes had been recognized in unicellular or filamentous species. Nonetheless, regardless of the intense circumstances skilled by extremophile species, we discovered no proof for growth of ROS-related gene households in these species in comparison with different Eukaryotes. Tardigrades and rotifers do present ROS gene expansions that may very well be associated to their excessive existence, though a excessive charge of lineage-specific horizontal gene switch occasions, coupled with current tetraploidy in rotifers, may clarify this commentary. This implies that the basal Eukaryotic ROS scavenging techniques are adequate to take care of ROS homeostasis even beneath essentially the most excessive circumstances. The MOB household proteins are constituted by extremely conserved eukaryote kinase sign adaptors which are usually important each for cell and organism survival.
Traditionally, MOB household proteins have been described as kinase activators taking part in Hippo and Mitotic Exit Community/ Septation Initiation Community (MEN/SIN) signaling pathways which have central roles in regulating cytokinesis, cell polarity, cell proliferation and cell destiny to manage organ progress and regeneration. In metazoans, MOB proteins act as central sign adaptors of the core kinase module MST1/2, LATS1/2, and NDR1/2 kinases that phosphorylate the YAP/TAZ transcriptional co-activators, effectors of the Hippo signaling pathway.
To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins
To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Symbiotic Origin of Apoptosis

The progress of evolutionary biology has revealed that symbiosis performed a primary function within the evolution of advanced eukaryotic organisms, together with people. Mitochondria are literally simplified endosymbiotic micro organism presently enjoying the function of mobile organelles. Mitochondrial domestication occurred on the very starting of eukaryotic evolution. Mitochondria have two totally different primary features: they produce vitality utilizing oxidative respiration, and so they provoke totally different types of apoptotic programmed/regulated cell dying.
Apoptotic programmed cell dying might have totally different cytological varieties. Mechanisms of apoptotic programmed cell dying exist even within the unicellular organisms, and so they play a primary function within the improvement of advanced multicellular organisms, corresponding to fungi, inexperienced vegetation, and animals. Multicellularity was independently established many occasions amongst eukaryotes. There are indications that apoptotic programmed cell dying is a trait required for the institution of multicellularity. Regulated cell dying is initiated by many alternative parallel biochemical pathways. It’s usually accepted that apoptosis developed throughout mitochondrial domestication.

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx213618
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx213619
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx301131
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

abx230470-100ug 100 ug
EUR 481

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

abx330689-100ul 100 ul
EUR 425

Apoptosis Protease Activating Factor 1 (APAF1) Antibody

20-abx327509
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (HRP)

20-abx303073
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (FITC)

20-abx303074
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Protease Activating Factor 1 (APAF1) Antibody (Biotin)

20-abx303075
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human apoptosis protease activating factor- 1 ELISA Kit

ELA-E1054h 96 Tests
EUR 824

Mouse apoptosis protease activating factor- 1 ELISA Kit

ELA-E1054m 96 Tests
EUR 865

Pig Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx360758-96tests 96 tests
EUR 825

Rabbit Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx363578-96tests 96 tests
EUR 825

Chicken Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx355615-96tests 96 tests
EUR 825

Monkey Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx358759-96tests 96 tests
EUR 825

Human Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx054561-96tests 96 tests
EUR 786

Human Apoptosis Protease Activating Factor 1 (APAF1) CLIA Kit

abx196456-96tests 96 tests
EUR 825

Human Apoptosis Protease Activating Factor 1 (APAF1) ELISA Kit

abx252034-96tests 96 tests
EUR 707

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit

EH2654 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human apoptosis protease activating factor-1,ICAD ELISA Kit

CN-03380H1 96T
EUR 436

Human apoptosis protease activating factor-1,ICAD ELISA Kit

CN-03380H2 48T
EUR 287

Human apoptosis protease activating factor-1, Apaf-1 ELISA Kit

CSB-E08996h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human apoptosis protease activating factor-1, Apaf-1 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human apoptosis protease activating factor-1, Apaf-1 ELISA Kit

1-CSB-E08996h
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human apoptosis protease activating factor-1, Apaf-1 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

GA-E1852HM-48T 48T
EUR 289

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

GA-E1852HM-96T 96T
EUR 466

Human apoptosis protease activating factor-1,Apaf-1 ELISA Kit

201-12-1836 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human apoptosis protease activating factor-1(Apaf-1)ELISA Kit

QY-E03796 96T
EUR 394

ELISA kit for Mouse APAF1 (Apoptosis Protease Activating Factor 1)

E-EL-M0143 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human APAF1 (Apoptosis Protease Activating Factor 1)

E-CL-H0393 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)

KTE62504-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human APAF1 (Apoptosis Protease Activating Factor 1)

E-EL-H0481 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human APAF1 (Apoptosis Protease Activating Factor 1) in samples from Serum, Plasma, Cell supernatant

Human Apaf-1 (Apoptosis Protease Activating Factor-1) Control/blocking peptide

APAF11-P 100 ug
EUR 164

Rabbit Anti-HumanApaf-1 (Apoptosis Protease Activating Factor-1) IgG, aff pure

APAF11-A 100 ug
EUR 482

Human Apoptotic protease-activating factor 1 (APAF1)

1-CSB-YP001885HU
  • EUR 586.00
  • EUR 299.00
  • EUR 2172.00
  • EUR 900.00
  • EUR 1442.00
  • EUR 382.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Apoptotic protease-activating factor 1(APAF1),partial expressed in Yeast

Apoptotic Protease-Activating Factor 1 (APAF-1) Antibody

20-abx121271
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Apoptotic Protease-Activating Factor 1 (APAF-1) Antibody

20-abx009588
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Apoptotic Protease-Activating Factor 1 (APAF-1-ALT) Antibody

20-abx013022
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Rat Apaf1/ Apoptotic protease-activating factor 1 ELISA Kit

E0077Ra 1 Kit
EUR 646

Mouse Apaf1/ Apoptotic protease-activating factor 1 ELISA Kit

E0107Mo 1 Kit
EUR 571

Rat Apaf1(Apoptotic protease-activating factor 1) ELISA Kit

ER0427 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

ELISA kit for Rat Apoptotic protease-activating factor 1

EK2658 96 tests
EUR 721
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Apoptotic protease-activating factor 1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Apoptotic protease- activating factor 1, APAF1 ELISA KIT

ELI-03414h 96 Tests
EUR 824

Mouse Apoptotic protease- activating factor 1, Apaf1 ELISA KIT

ELI-03416m 96 Tests
EUR 865

Channel Activating Protease 1 (CAP1) Antibody

20-abx111356
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Channel Activating Protease 1 (CAP1) Antibody

20-abx214652
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Channel Activating Protease 1 (CAP1) Antibody

20-abx214653
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Channel Activating Protease 1 (CAP1) Antibody

20-abx171674
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Apaf1 ELISA Kit| Rat Apoptotic protease-activating factor 1 ELIS

EF017272 96 Tests
EUR 689

Human ICE protease-activating factor(IRAP)ELISA Kit

GA-E0688HM-48T 48T
EUR 289

Human ICE protease-activating factor(IRAP)ELISA Kit

GA-E0688HM-96T 96T
EUR 466

Human ICE protease-activating factor,IRAP ELISA Kit

201-12-0672 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human ICE protease-activating factor(IRAP)ELISA Kit

QY-E04867 96T
EUR 361

Human ICE protease-activating factor,IRAP ELISA Kit

CN-04462H1 96T
EUR 455

Human ICE protease-activating factor,IRAP ELISA Kit

CN-04462H2 48T
EUR 304

Lethal factor Protease Substrate 1, Internally quenched Coumarin peptide substrate for monitoring LF protease activity (19aa)

LFPS-1 500 ug
EUR 529

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-100ug

QP8984-ye-100ug 100ug
EUR 670

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-10ug

QP8984-ye-10ug 10ug
EUR 308

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-1mg

QP8984-ye-1mg 1mg
EUR 2747

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-200ug

QP8984-ye-200ug 200ug
EUR 1069

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-500ug

QP8984-ye-500ug 500ug
EUR 1804

Recombinant Human Apoptotic protease-activating factor 1 Protein, His, Yeast-50ug

QP8984-ye-50ug 50ug
EUR 417

Channel Activating Protease 1 (CAP1) Antibody (FITC)

20-abx271303
  • EUR 509.00
  • EUR 258.00
  • EUR 1525.00
  • EUR 704.00
  • EUR 411.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Channel Activating Protease 1 (CAP1) Antibody (Biotin)

20-abx271569
  • EUR 481.00
  • EUR 244.00
  • EUR 1414.00
  • EUR 662.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

ELISA kit for Human ICE protease-activating factor (IRAP)

KTE62551-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human ICE protease-activating factor (IRAP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human ICE protease-activating factor (IRAP)

KTE62551-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human ICE protease-activating factor (IRAP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human ICE protease-activating factor (IRAP)

KTE62551-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human ICE protease-activating factor (IRAP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

BAFF B-cell Activating Factor Human Recombinant Protein

PROTQ9Y275-1 Regular: 20ug
EUR 317
Description: BAFF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton. ;The BAFF is purified by proprietary chromatographic techniques.

EZCut? SUMO Protease 1 Agarose Beads

M1028-1
EUR 240

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

SEG321Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Channel Activating Protease 1 (CAP1) in serum, plasma, urine and other biological fluids.

Human Channel Activating Protease 1 (CAP1) ELISA Kit

4-SEG321Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Channel Activating Protease 1 (CAP1) in samples from Serum, plasma, urine and other biological fluids. with no significant corss-reactivity with analogues from other species.

Protease-Activated Receptor-2 Activating Peptide

HY-P1308 10mM/1mL
EUR 366

Apoptosis-Inducing Factor

PR27201 5 ug
EUR 191

TurboTEV Protease, Recombinant

9205-1
EUR 615

Human ice Protease-Activating Factor (IPAF) or CARD12 Control/blocking peptide

IPAF11-P 100 ug
EUR 164

Rabbit Anti-Human Ice Protease-Activating Factor (IPAF) or CARD12 antiserum

IPAF11-S 100 ul
EUR 457

ELISA kit for Human CAP1 (Channel Activating Protease 1)

ELK5109 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Channel Activating Protease 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human CAP1 (Channel Activating Protease 1)

ELK3115 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Channel Activating Protease 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Nuclear Apoptosis Inducing Factor 1 Protein

20-abx263420
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg

DiscoveryProbe? Apoptosis Compound Library

L1036-.1 100 uL/well(10 mM solution)
EUR 3472

DiscoveryProbe? Protease Inhibitor Library

L1035-.1 100 uL/well(10 mM solution)
EUR 3390

Turbo3C (HRV3C) Protease, Recombinant

9206-1
EUR 468

Recombinant Activating Transcription Factor 1 (ATF1)

4-RPB346Hu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Activating Transcription Factor 1 expressed in: E.coli

Recombinant Activating Transcription Factor 1 (ATF1)

4-RPB346Mu01
  • EUR 490.66
  • EUR 234.00
  • EUR 1564.96
  • EUR 588.32
  • EUR 1076.64
  • EUR 391.00
  • EUR 3762.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Activating Transcription Factor 1 expressed in: E.coli

Recombinant Activating Transcription Factor 1 (ATF1)

4-RPB346Ra01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Activating Transcription Factor 1 expressed in: E.coli

Activating Transcription Factor 1 (ATF1) Antibody

20-abx131007
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

20-abx110784
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx322143
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx004436
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx103391
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

20-abx103392
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

abx038463-100ug 100 ug
EUR 391

Activating Transcription Factor-1 Protein (Recombinant)

20-abx073863
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Activating Transcription Factor 1 (ATF1) Antibody

abx148385-100ug 100 ug
EUR 439

Activating Transcription Factor 1 (ATF1) Antibody

20-abx009565
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx013416
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Activating Transcription Factor 1 (ATF1) Antibody

abx432374-200ul 200 ul
EUR 384

Activating Transcription Factor 1 (ATF1) Antibody

20-abx212729
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

20-abx212730
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Activating Transcription Factor 1 (ATF1) Antibody

abx230659-100ug 100 ug
EUR 509

Activating Transcription Factor 1 (ATF1) Antibody

20-abx329224
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Activating Transcription Factor 1 (ATF1) Antibody

abx332273-100ul 100 ul
EUR 425

Activating Transcription Factor 1 (ATF1) Antibody

20-abx325979
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Activating Transcription Factor 1 Recombinant Protein

92-277 0.05 mg
EUR 684.5
Description: Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the Tax-responsive element (TRE) of HTLV-I. ATF1 mediates PKA-induced stimulation of CRE-reporter genes, represses the expression of FTH1 and other antioxidant detoxification genes, triggers cell proliferation and transformation. ATF1 is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and CDK3. Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Human Apoptosis-inducing factor 1, mitochondrial (AIFM1)

1-CSB-EP001492HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Apoptosis-inducing factor 1, mitochondrial(AIFM1),partial expressed in E.coli

Human Apoptosis-Inducing Factor 1 (AIF) Antibody

35690-05111 150 ug
EUR 261

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

20-abx126823
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

20-abx111033
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Nuclear Apoptosis-Inducing Factor 1 (NAIF1) Antibody

20-abx318382
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

20-abx002005
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

abx038388-100ug 100 ug
EUR 391

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

abx034154-400ul 400 ul
EUR 523

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

abx034154-80l 80 µl
EUR 286

Nuclear Apoptosis-Inducing Factor 1 (NAIF1) Antibody

20-abx005986
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

20-abx008455
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

abx431855-200ul 200 ul
EUR 384

Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

abx432295-200ul 200 ul
EUR 384
Nonetheless, there are totally different hypothetical fashions of the origin of apoptosis. The phylogenetic research of my group point out that apoptosis most likely developed throughout an evolutionary arms race between host ancestral eukaryotic predators and ancestral prey mitochondria (named protomitochondria). Protomitochondrial prey produced many alternative toxins as a protection in opposition to predators. From these toxins developed extant apoptotic components. There are indications that cardio respiration and apoptosis co-evolved and are functionally linked in extant organisms. Perturbations of apoptosis and oxidative respiration are ceaselessly noticed throughout neoplastic transition. Our group confirmed that perturbations of apoptosis in yeasts additionally trigger perturbations of oxidative respiration.

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